SpatialTCR: An integrated platform for high-resolution spatial sequencing of T cell receptor repertoires
- Developed a high-resolution spatial TCR profiling method leveraging Stereo-seq, enabling accurate reconstruction of TCR alpha and beta chains directly from tissue sections.
- Created a dedicated computational pipeline for reliable chain pairing, clonotype mapping, and integration with spatial transcriptomic data.
- Applied the platform to human tissues, revealing spatial T cell clonotype distributions and immune microenvironments with high confidence.
